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Track 12: Cancer Metastasis

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Related Sessions

Track 1-Cancer

Sub Topics: Cancer, Types of Cancer, Causes of Cancer, Symptoms of Cancer,...

Track 2 -Oncology

Sub Tracks:

Here's an overview of common oncology sub-tracks:

Medical Oncology | Radiation Oncology...

Scientific Sessions

Track 1-Cancer
Track 2 -Oncology
Track 3: Immunotherapy
Track 4: Radiotherapy
Track 5:Chemotherapy
Track 6: Surgical Oncology
Track 7:Hormone-therapy
Track 8: Leukemia
Track 9:cancer genetics
Track 10:Cancer Epigenetics
Track 11:Tumor microenvironment
Track 12: Cancer Metastasis
Track 13:Breast Cancer
Track 14: Lung cancer
Track 15:Colorectal Cancer
Track 16: Prostate Cancer
Track 17:Skin Cancer
Track 18: Blood Cancer
Track 19:Brain Tumors
Track 20: Ovarian Cancer
Track 21: Head and Neck Cancer
Track 22:Pancreatic Cancer
Track 23: Liver Cancer
Track 24: Bone Cancer
Track 25:Cancer Stem Cells
Track 26:Cancer Biomarkers
Track 27: Precision Oncology
Track 28: Cancer Prevention
Track 29:Cancer Epidemiology
Track 30:Cancer Screening

Track 12: Cancer Metastasis

Sub Tracks: cancer metastasis
Primary Tumor: - Genetic Mutations - Tumor Microenvironment - Angiogenesis Invasion: - Epithelial-to-Mesenchymal Transition (EMT) - Matrix Degradation - Migration Factors Intravasation: - Interaction with Blood Vessels - Enzymes like MMPs - Cell Survival Mechanisms Circulation: - Circulating Tumor Cells (CTCs) - Platelet Shielding - Immune Evasion Extravasation: - Endothelial Adhesion - Vascular Permeability - Exit from Vasculature Secondary Tumor: - Colonization - Dormancy vs. Proliferation - Organ-specific Factors
What is cancer metastasis?
Cancer metastasis refers to the process by which cancer cells spread from their original (primary) site to other parts of the body, forming new (secondary) tumors. This is a hallmark of cancer progression and often signifies a more advanced and serious stage of the disease.
Key steps in metastasis:

  • Detachment from the Primary Tumor: Cancer cells break away from the primary tumor, overcoming cellular adhesion mechanisms.

  • Invasion into Surrounding Tissues: The cells invade nearby tissues by degrading the extracellular matrix using enzymes like matrix metalloproteinases (MMPs).

  • Intravasation: Cancer cells enter nearby blood vessels or lymphatic vessels.

  • Survival in Circulation: Within the bloodstream or lymphatic system, cancer cells must survive immune attacks and shear forces.

  • Extravasation: The cells exit the blood or lymphatic vessels and migrate into distant tissues.

  • Colonization: The cancer cells grow and form secondary tumors in the new location, a process that often involves adapting to the microenvironment of the new tissue.